Multifunctional saffron

Multifunctional saffron

Keywords: Saffron; safety medicine; multi-function; antidementia; preventive medicine

Saffron is one of the well-known natural products and has been investigated widely. It also has a long eating experience of just about 3,000 years in Europe as a spice, coloring agent and herb medicine, and was listed in the Chinese Compendium of Materia Medica, Honzo-gangmoku published in 1590. Nowadays saffron has been authorized as Generally Recognized as Safe by the American Food and Drug Administration resulting that the most important issue for clinical use of saffron is safety without side effect. Huge in vitro and in vivo researches on saffron and its constituent have been accumulated to prove the wide pharmacological activities such as anticancer, antioxidant, anti-inflammation, anti-apoptosis, learning and memory, non-Rapid eye movement sleeping and antidementia and recently concentrated to neurological fields, notably dementia of which no preventive drug is found in the world although the dementia population has been increasing quickly. Under this status “Multifunctional saffron” is seemed to be the best choice for converging accumulated knowledge for finding of preventive medicine for dementia.

The combinations of Traditional Chinese medicine or Kampo formulas with saffron have been clinically used for mental disease. From this evidence its combination prescription may open a possibility of new therapeutic methodology for dementia patients. In fact, the combination of saffron and the other herb medicines has been developing to a new medicine against prevention of dementia. Hopefully more research on saffron and its constituent will be expanding and considered more including wide dimensions to create a preventive medicine for dementia in near future.

As guest-editor of the “Multifunctional saffron” series, I would appreciate for the support of authors, reviewers and Longhua Chinese Medicine staff, and further I believed that this publication can’t be succeeded to publish without their help.


Funding: None.


Provenance and Peer Review: This article was commissioned by the editorial office, Longhua Chinese Medicine for the series “Multifunctional Saffron”. The article did not undergo external peer review.

Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at The series “Multifunctional Saffron” was commissioned by the editorial office without any funding sponsorship. YS served as the unpaid Guest Editor of the series and serves as an unpaid Associate Editor-in-Chief of Longhua Chinese Medicine from September 2022 to August 2024. The author has no other conflicts of interest to declare.

Ethical Statement: The author is accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See:

Yukihiro Shoyama

Yukihiro Shoyama

Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Japan. (Email:

Received: 05 December 2022; Accepted: 21 December 2022; Published: 30 December 2022.

doi: 10.21037/lcm-22-31

doi: 10.21037/lcm-22-31
Cite this article as: Shoyama Y. Multifunctional saffron. Longhua Chin Med 2022;5:31.

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