Fu xie theory: a theoretical basis for the future of medicine

Fu xie theory: a theoretical basis for the future of medicine

Darong Wu

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China

Correspondence to: Darong Wu. The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China. Email: darongwu@gzucm.edu.cn.

Comment on: Zhang T, Gu L. A brief introduction to fu xie. Longhua Chin Med 2022;5:17.

Received: 04 July 2022; Accepted: 22 July 2022; Published: 30 September 2022.

doi: 10.21037/lcm-2022-01

Global interest in traditional and complementary medicine (T&CM) is undergoing a revival. A number of T&CM, such as traditional Chinese medicine, have been used for society health care for thousands of years. According to the World Health Organization (WHO) 2019 report (1), lack of research data was raised by 99 Member States to be their top difficulty they faced with regard to regulatory issues related to the practice of T&CM. To learn how T&CM work and to elucidate their underlying mechanisms of action in diseases prevention and treatment remains an important subject.

The article entitled “A brief introduction of fu xie” is a case in point. It aims to review and evolve the fu xie theory, in regards to the advances in the doctrine of febrile disease and the high theoretical and practical significance in immune-related diseases.

Some fundamental theories of T&CM have gradually been found its material bases, like the link between gut microbes and lung disease (2) partially reflecting the doctrine of lung and the large intestine being interior-exteriorly related. However, the theoretical and practical principle of fu xie associating with immune-related diseases is a research area that most of the mechanisms are still unknown. In the ancient Chinese medical books, as the author mentioned in this article, fu xie had six categories; it is closely connected with some insidious regions, e.g., skin, muscles, bones, moyuan (membrane source), Shaoyin (kidney meridian), fatty membrane of Sanjiao; it has unique pathogenic features, etiologies and clinical manifestations, as well as accordingly therapeutic methods.

To keep a child healthy, keep him feel a little hungry and cold. This was addressed by a famous pediatrician Shirong Zeng of the Yuan Dynasty in his book “Huo You Xin Shu” (3). For hundreds of years, it was only an old saying based on the theory of traditional Chinese medicine. Until Prof. Ohsumi, who won a Nobel prize in 2016, found that (4-6) in response to nutrient starvation, autophagy (macroautophagy) as an intracellular recycling system played an important role in human disease and physiology. One of the primary function of autophagy, i.e., the starvation response in single-cell organisms such as yeasts, it extends up through to humans. Dysfunction of autophagy is associated with a number of diseases, such as cancer, neurodegeneration, microbial infection and ageing (7). Similarly, the fu xie theory Prof. Zhang and his colleague provided through this review, might someday become a key theoretical basis of certain mechanism that would attract the interests of scientists and clinicians to harness its process for the purpose of improving human health.


Funding: None.


Provenance and Peer Review: This article was commissioned by the editorial office, Longhua Chinese Medicine. The article did not undergo external peer review.

Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at https://lcm.amegroups.com/article/view/10.21037/lcm-2022-01/coif). The author has no conflict of interest to declare.

Ethical Statement: The author is accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately addressed.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.


  1. World Health Organization. WHO global report on traditional and complementary medicine. 2019.
  2. Chakradhar S. A curious connection: Teasing apart the link between gut microbes and lung disease. Nat Med 2017;23:402-4. [Crossref] [PubMed]
  3. Zeng SR. Huo You Xin Shu. Beijing: China Press of Traditional Chinese Medicine, 2016.
  4. Nakatogawa H, Suzuki K, Kamada Y, et al. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 2009;10:458-67. [Crossref] [PubMed]
  5. Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011;147:728-41. [Crossref] [PubMed]
  6. Ohsumi Y. Historical landmarks of autophagy research. Cell Res 2014;24:9-23. [Crossref] [PubMed]
  7. Mizushima N, Levine B, Cuervo AM, et al. Autophagy fights disease through cellular self-digestion. Nature 2008;451:1069-75. [Crossref] [PubMed]
doi: 10.21037/lcm-2022-01
Cite this article as: Wu D. Fu xie theory: a theoretical basis for the future of medicine. Longhua Chin Med 2022;5:21.

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